منابع مشابه
SwissPalm: Protein Palmitoylation database
Protein S-palmitoylation is a reversible post-translational modification that regulates many key biological processes, although the full extent and functions of protein S-palmitoylation remain largely unexplored. Recent developments of new chemical methods have allowed the establishment of palmitoyl-proteomes of a variety of cell lines and tissues from different species. As the amount of infor...
متن کاملPalmitoylation-dependent protein sorting
S-palmitoylation is a posttranslational modification that regulates membrane-protein interactions. However, palmitate is more than just a hydrophobic membrane anchor, as many different types of protein are palmitoylated, including transmembrane proteins. Indeed, there is now compelling evidence that palmitoylation plays a key role in regulating various aspects of protein sorting within the cell.
متن کاملPalmitoylation of serotonin receptors.
The covalent attachment of palmitic acid to one or more cysteine residues (S-palmitoylation) is a widespread modification of signalling proteins. With the finding that palmitoylation is a dynamic process, it is now widely accepted that repeated cycles of palmitoylation/depalmitoylation could be involved in the regulation of multiple signalling processes. Palmitoylation also represents a common ...
متن کاملLearning by palmitoylation
Proteases commit microbicide hite blood cells use proteases to kill their targets, according to new results from Emer Reeves, Hiu Lu, Anthony Segal (University College, London, England), and colleagues. The findings contradict previously accepted notions that reactive oxygen species (ROSs) are the killing agents. ROSs like superoxide are produced by NADPH oxidase activity when white blood cells...
متن کاملProtein palmitoylation in membrane trafficking
Introduction Protein palmitoylation was first described more than 20 years ago for the myelin proteolipid protein, but the functional significance of this post-translational modification remains obscure. Progress has been hampered by the lack of specific inhibitors for acylation and because of the difficulty of developing an assay to isolate the palmitoylating enzyme(s). Palmitoylation generall...
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ژورنال
عنوان ژورنال: Science
سال: 2013
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.342.6154.17-c